Relative Contributions of the Novel Diarylquinoline TBAJ-876 and its Active Metabolite to the Bactericidal Activity in a Murine Model of Tuberculosis.

Journal:

The Journal of infectious diseases, Volume: 230, Issue: 6

Published:

December 16, 2024

PMID:

38941358

Authors:

Saskia E Mudde SE, Nicole C Ammerman NC, Marian T Ten Kate MT, Nader Fotouhi N, Manisha U Lotlikar MU, Hannelore I Bax HI, Jurriaan E M de Steenwinkel JEM

Access Paper

DOI: 10.1093/infdis/jiae332

PMID: 38941358

Abstract:

TBAJ-876 is a next-generation diarylquinoline. In vivo, diarylquinoline metabolites are formed with activity against Mycobacterium tuberculosis. Species-specific differences in parent drug-to-metabolite ratios might impact the translational value of animal model-based predictions. This study investigates the contribution of TBAJ-876 and its major active metabolite, TBAJ-876-M3 (M3), to the total bactericidal activity in a mouse tuberculosis model.

Courtesy of the U.S. National Library of Medicine